The second set in the Kamigawa block. It contains 165 cards. The set's story is inspired by Japanese medieval myths and revolves around the battle between spirits (kami) and living beings. The set's expansion symbol is a shuriken, or ninja throwing star.

Betrayers of Kamigawa introduces two new mechanics to the game.

• Ninjutsu allows a player to put a Ninja creature card from his or her hand into play tapped and attacking by paying a cost and returning an attacking, unblocked creature he or she controls to its owner's hand.
• Offering allows the player to partially pay for a spell by sacrificing a creature of a certain creature type, and lets the spell be played as an instant. This ability is used on five Spirit creatures, the patron spirits of five non-human species in Kamigawa.                                                                                                                             

Betrayers also features the first non-wall creatures with defender.