May 1999 - 143 Cards

Urza's Destiny expanded further on some of the mechanics introduced earlier in the block. Several creatures and enchant creatures trigger various abilities when put into a graveyard from play. Some permanents have the ability to be sacrificed for 2 mana to draw a card, like a cycling ability for cards in play that are no longer useful. Three creatures have this ability in addition to a "graveyard from play" ability. There is class of spells that become more effective with the number of cards of a certain color the caster reveals from his/her hand, and cycle of creatures with abilities that emulate those spells.

Urza's Destiny also introduced a cycle of cards that removes a card of a certain type from the game, and then also removes all copies of that card not in play from its controller's deck. Called "Lobotomy" cards due to their resemblance of the card of that name, they were later reprinted in Betrayers. Another noteworthy aspect is that Urza's Destiny was the first set to be printed under the then-new 6th Edition rules changes; the most notable change seen on cards is the text of creatures - as in creature types. Whereas a card like Llanowar Elves would be given "Summon Elf" in previous sets, it would now be given "Creature - Elf".

Story: With the skyship Weatherlight completed, Urza now works on a eugenics program to create a perfect crew for it, as well as engineering a race of soldiers to fight the Phyrexian invasion. One of his geneticists, Gatha, defects, and uses his knowledge to improve the Keldon race. Meanwhile, the Phyrexians create the plane of Rath as a staging ground for the invasion.